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The battle against SARS and MERS coronaviruses: Reservoirs and Animal Models

Identifieur interne : 000509 ( Pmc/Checkpoint ); précédent : 000508; suivant : 000510

The battle against SARS and MERS coronaviruses: Reservoirs and Animal Models

Auteurs : Shu-Ran Gong ; Lin-Lin Bao

Source :

RBID : PMC:6388065

Abstract

Abstract

In humans, infection with the coronavirus, especially the severe acute respiratory syndrome coronavirus (SARS‐CoV) and the emerging Middle East respiratory syndrome coronavirus (MERS‐CoV), induces acute respiratory failure, resulting in high mortality. Irregular coronavirus related epidemics indicate that the evolutionary origins of these two pathogens need to be identified urgently and there are still questions related to suitable laboratory animal models. Thus, in this review we aim to highlight key discoveries concerning the animal origin of the virus and summarize and compare current animal models.


Url:
DOI: 10.1002/ame2.12017
PubMed: 30891557
PubMed Central: 6388065


Affiliations:


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PMC:6388065

Le document en format XML

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Lin‐lin Bao, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing, China.
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